منابع مشابه
Biological activity of macromomycin.
Macromomycin (MCR) is a polypeptide antimuor antibiotic isolated from the culture broth of Streptomyces macromomyceticus. Antitumor activities of MCR were examined against three different tumor system, i.e., EHRLICH ascites carcinoma, L1210 leukemia and LEWIS lung carcinoma. Daily intraperitoneal treatment with MCR for 5 days showed a strong inhibition against EHRLICH ascites carcinoma. Both si...
متن کاملBactericidal activity of macromomycin, a antitumor antibiotic.
Susceptibility testing by the broth dilution method showed that all the gram-positive but only some of the gram-negative bacteria tested were susceptible to the antitumor antibiotic, macromomycin (MCR; NSC 170105). The minimal inhibitory concentration for the susceptible organisms was less than 3 mug/ml. The action of MCR was bactericidal; however, at very high concentrations (50 mug/ml and abo...
متن کاملProduction of a macromomycin (MCR)-monoclonal antibody conjugate and its biological activity.
Macromomycin (MCR), an unique membrane-reactive anticancer antibiotic, was incubated with murine monoclonal anti-HLA IgG1 antibody (H-1) in the presence of carbodiimide. The resulting mixture was fractionated with a Sephadex G-200 column. The first and second fractions were shown to contain MCR-(H-1) conjugate by the elution profile, as well as by the Sarcina lutea growth inhibition assay and O...
متن کاملEffects of macromomycin on the ultrastructure and biological properties of cultured mammalian cells.
Macromomycin is shown to inhibit the biosynthesis of RNA, DNA, and protein in cultured cells of KB, HBL-100, SW-613, MCF-7, and A1Ab. There was no substantial increase in cell numbers in cultures containing macromomycin (5 microgram/ml), but after 24 to 48 hr the cells were two to three times the diameter of control cells with concomitant increase in cell protein. The ultrastructural changes in...
متن کاملUranyle Complexes: synthesis, evaluation of biological activity
In this research, some of the inorganic complexes of uranyl with N- donor ligandswere synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center ofuranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.The structure is linear (O=U=O, 180) and usually stable. So other ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1979
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.32.340